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ZEISS Microscopy Knowledge Base

Release Notes

SIS Converter 4.5

Version 4.5 2026-03-17

New features

  • Improved: Import tiled LaVision FastTile Blaze data
  • Improved: Normalization of the color range for CZI float datasets
  • Support added for more compression types of HDF5 blocks (e.g. used by some IMS datasets)

Bugfixes

  • Wrong tile positions for Perkin Elmer well plate data without orientation matrix specified in the metadata
  • Import problems for data from Perkin Elmer Acapella
  • Potential wrong colors were imported from some Aperio-SVS data
  • Wrong pixel size imported from some Aperio-SVS data
  • Import of different image types as channels from Yokogawa
  • Import of BigDataViewer with non-consecutive setups
  • Various smaller bug fixes and improvements

SIS Converter 4.3

Version 4.3 2025-04-04

New features

  • Thermo Fisher CellInsight CX7 media handler
  • ImageXpress MetaSeries Single/Multi-plane TIFF media handler
  • Well plate ID is imported from well plate file formats (e.g. InCell, Perkin Elmer, Yokogawa)
  • Support for jpeg-compressed conversions
  • Ability to stitch fields of a well during import (if positions are avialable e.g. in Yokogawa data)
  • Media handler can be disabled/enabled on the fly now in the Preferences
  • Enhanced System Check utility
  • Improved: Meta Image Series / ImageXpress import
  • Improved: support for JPEG2000 compressed TIFF data
  • Improved: use emission filter name as fallback channel name for InCell XDCE data
  • Improved: unified TIFF media handler improved: proper import pixel size Z from Yokogawa data
  • Improved: better dimension handling for planes or time points in DICOM

Bug fixes

  • Image set names for well plate datasets (e.g. from ImageXpress or Yokogawa)
  • Potential import problems for 32bit float TIFF data
  • Problems importing multimodal Yokogawa data
  • Some VSI were imported with a wrong channel order
  • Import *.am data from Avizio
  • Import of stitched LaVision datasets
  • Potential memory leak if writing (with compression) to a full disk
  • Problems with subblocks in CZI imports
  • Potential line break problems with ImageJ Tiff import
  • Rare problems with unusual OME meta data
  • Problems with Jpeg2000 compressed Olympus VSI files
  • Incorrect channel names for imported VSI files
  • Correct metadata for multiple image sets imported from LIF
  • Potential import problems for Olympus OIR data
  • Make sure a license is not blocked too long after closing SIS Converter
  • Switched to .Net 8

SIS Converter 4.1

Version 4.1 2023-05-04

New features

  • Drag & Drop of folders including several files with the specification of conversion type - multiple input files to be merged or converted independently (1:1)
  • Improved handling to avoid unintentional overwriting of image data
  • Option to add data as new Image Sets if there is already a target file with the same name
  • Define behavior if a target file already exists (Preference option)
  • Import of Inspector OBF/MSR data
  • Support for the newest LaVision OME format

Bug fixes

  • Pixel size for multiple image sets using custom import
  • CZI import with different pixel types (in one data set)
  • Possible problem with Nikon ND2 import for pre-stitched data
  • Avoid conversion history corruption
  • Small UI glitches
  • Separate Start Menu entries for the free and the pro version
  • Avoid infinite loop with the same source and destination folders (SIS Converter PRO)
  • Improved robustness for unexpected termination

SIS Converter 4.0

Version 4.0 2022-10-24

New features

  • Media handler for reading Perkin Elmer Operetta and Columbus datasets
  • Support for ZSTD compression in CZI import
  • Added details-part to dialog for 1-to-1 conversion after drag and drop
  • Improved: import the names of the channels of an OME TIFF

Bug fixes

  • License tool is not opened
  • Possible out of bounds access for .msr/.obf files
  • Bug which caused error message for certain .dcm files
  • Bug for certain .vsi files concerning gamma-parameter range
  • Problems with importing SVS files
  • Scenes order for CZI imports
  • Several smaller UI fixes

SIS Converter 3.5.1

Version 3.5.1 2021-11-29

New features

  • Support for importing ND2 float data
  • General better support to import HCA well plate datasets
  • Import of GE XDCE datasets
  • Import of Yokogawa MLF and MMD datasets
  • Improved: Support for Zeiss CZI well plate datasets
  • Improved: Nikon ND2 import by using the latest ND2Read SDK
  • Improved: Better support for importing Leica LEI time series
  • Improved: Olympus import uses the latest IDAL library
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